Quindor here. Running 3 servers 24H now.
Normally I play on server 1, which is mostly the updated nightly build (depends on how busy I am that day).
Anyways, that mostly all works just peachy.
Problem is that about 2 builds ago or so, the multiplayer has become increasingly more unstable.

I think it started when SVN change "r1407 | truelight | 2005-01-06 23:31:58 +0100 (Thu, 06 Jan 2005) | 20 lines". But I'm not really sure though.
What happens is that the server will start off just fine. Everybody can join, login and play happily....
Then more and more desync error (10045) will start happening. Then everyone gets kicked, and the server immediatly desync's when you try to join. It downloads the map, and BAM! your back in the main screen again with a RedBox saying you had a desync problem.
Server log reports this :
dgb: [NET] Quindor reported an error and is closing his connection (desync error).
Not sure how to fix this. Only way to get back into the server again is to close it and restart it again......
Again, these problems only started about 2 nightly builds ago or so that I can remember. Before that it played perfectly fine!!
I hope that is enough information. I'll server 1 in the "broken" state, so everything/anyone can try and join and get kicked immediatly, to see what happens.
The map it's currently playing I only built like 7 trains or something and I was the only company.
I tested this problem with 4 different players on different machines in different locations on different Os'ses even. All have the same problem.

Regards and keep up the good work!
Quindor