I'll tell you as soon as my current game ends and I start another one.I would appreciate some feedback from players on if the sign spam is too annoying or if you can live with it.

Btw, I have a suggestion (note: I speak about playing with FIRS).
It's about the different cargo types necessary for a city to grow up. Some of them cannot always be delivered to a city, because there is not a corresponding industry. In FIRS, it's the case for COAL, MILK, RCYC, ENSP and MNSP.
I know that you already discussed that point and you suggest playing with less towns to increase the territory size, but even like that, it's not easy to have the possibility to deliver each type of those cargos. Take the example of the MILK. It needs a dairy to process. At the moment, in my current game, I have 4 dairies on the whole map (1024*1024)

I suppose you included those processable cargos (like milk and coal) to discourage from sending all the coal of a map to one only station and improve distribution, but maybee is there another way (eventually not based on city growth ?) to achieve this. Or maybee, just taking out some cargos would make the thing. In FIRS, for example, you could take out MILK, COAL, RCYC (which anyway is present only from 1997) leaving ENSP and MNSP in the list of necessary cargos, which would anyway encourage to develop industries all over the map.
Another interesting possibility could be to consider all the industry cargos which are not originally intended to be delivered to a city as one only category, a sort of industrial category (which includes all the aboves cargos, and also any other industrial cargo, like IRON, GRAI, and all others) and make of this category as a whole a requirement for growth. In that way, you make it necessary to distribute industrial production all over the map, but you get rid of the problem of the presence of a single particular industry in a particular city.
This is just a suggestion, and it is up to you to see what you think about it. I'm still testing version 2, anyway, and I'm still not sure I perfectly understand how all works. I don't know if I was completely clear in all...